- One last kill, Robert Dugoni
- Credible threat, J. A. Jance
- Above the waterfall, a novel, Ron Rash
- The raven thief, Gigi Pandian
- The woman in the woods, John Connolly
- Beau death, Peter Lovesey
- The discreet charm of the big bad wolf, Alexander McCall Smith
- Listen to me, Tess Gerritsen
- Tea & treachery, Vicki Delany
- Ducks!, Deborah Underwood ; illustrated by T. L. McBeth
- Robert B. Parker's Angel eyes, Ace Atkins
- Read and gone, a haunted library mystery, Allison Brook
- The sanatorium, Sarah Pearse
- Vultures in the sky, Todd Downing ; introduction by James Sallis
- A world of curiosities, Louise Penny
- Conviction, Denise Mina
- Portrait of an unknown woman, Daniel Silva
- Of mushrooms and matrimony, Amy Patricia Meade
- All the Greys on Greene Street, Laura Tucker ; illustrations by Kelly Murphy
- City of gold, Len Deighton
- Child Zero, Chris Holm
- Checkmate to murder, a second World War mystery, E.C.R. Lorac ; with an introductio nby Martin Edwards
- A three book problem, Vicki Delany
- Every breath you take, Mary Higgins Clark & Alafair Burke
- Random in death, J. D. Robb
- Silent parade, Keigo Higashino ; translated by Giles Murray
- Minerva Keen's Detective Club, James Patterson and Keir Graff
- Nikki Tesla and the ferret-proof death ray, Jess Keating ; illustrated by Lissy Marlin
- A Christmas legacy, a novel, Anne Perry
- Squirm, Carl Hiaasen
- The unspoken, Ian K. Smith
- The best mystery stories of the year 2021, edited and with an introduction by Lee Child ; Otto Penzler, series editor
- Marathon, by Brian Freeman
- Emma in the night, Wendy Walker
- The body in the ballroom, R.J. Koreto
- Of mutts and men, Spencer Quinn
- An old man's game, an Amos Parisman mystery, Andy Weinberger
- The last confessions of Sylvia P., a novel, Lee Kravetz
- In this grave hour, a Maisie Dobbs novel, Jacqueline Winspear
- Whiskers in the dark, a Mrs. Murphy mystery, Rita Mae Brown & Sneaky Pie Brown ; illustrated by Michael Gellatly
- Denis ever after, Tony Abbott
- Don't let go, Harlan Coben
- A rip through time, Kelley Armstrong
- Rube Goldberg and his amazing machines, by Brandon T. Snider ; illustrated by Ed Steckley
- The hunter, Jennifer Herrera
- The spider, Lars Kepler ; translated from the Swedish by Alice Menzies
- Mysterious eye of the dragon, Geronimo Stilton ; illustrations by Danilo Loizedda, Antonio Campo, Daria Cerchi, and Serena Gianoli ; translated by Andrea Schaffer
- The Murder House, James Patterson and David Ellis
- Camp creepy, Kiersten White
- Death at Fort Devens, Peter Colt